Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844231 | 0.91 | MAPT (0.43) | PTGS2PPARDFFAR1RAB9ANPC1 | |
| SCHEMBL7843368 | 0.89 | PTGS2 (0.42) | PTGS2PTGDR2PPARDPTGS1FFAR1 | |
| SCHEMBL7833513 | 0.88 | PTGS2 (0.53) | PTGS2PTGDR2PPARDPTGS1ALOX5 | |
| SCHEMBL7844586 | 0.86 | PTGS2 (0.53) | PTGS2PTGDR2PPARDPTGS1RAB9A | |
| SCHEMBL7841302 | 0.82 | PTGS2 (0.51) | PTGS2PPARDPTGS1ALOX5RAB9A | |
| SCHEMBL7843555 | 0.81 | PTGS2 (0.51) | PTGS2PPARDPTGS1ALOX5RAB9A | |
| SCHEMBL6246548 | 0.80 | PTGS2 (0.65) | PTGS2PPARDPTGS1ALOX5 | |
| SCHEMBL7844271 | 0.80 | PTGS2 (0.53) | PTGS2PPARDPTGS1ALOX5RAB9A | |
| SCHEMBL7842156 | 0.79 | PTGS2 (0.48) | PTGS2PPARDPTGS1ALOX5RAB9A | |
| SCHEMBL7845661 | 0.78 | PTGS2 (0.49) | PTGS2PPARDPTGS1ALOX5RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |