Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.39 |
| ▸ | ITGAV | P06756 | 11/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.36 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6780175 | 0.88 | HSD17B10 (0.45) | MEN1KMT2AITGB1ITGA4HSD17B10 | |
| SCHEMBL7843533 | 0.85 | ITGB3 (0.45) | MEN1KMT2AITGB3ITGAVITGB1 | |
| SCHEMBL7835830 | 0.83 | ITGB3 (0.47) | MEN1KMT2AITGB3ITGAVITGB1 | |
| SCHEMBL7833465 | 0.82 | ITGB3 (0.44) | MEN1KMT2AITGB3ITGAVITGB1 | |
| SCHEMBL6778020 | 0.82 | ITGB3 (0.48) | MEN1KMT2AITGB3ITGAVITGB1 | |
| SCHEMBL6778181 | 0.81 | GPR132 (0.45) | MEN1KMT2AITGB3ITGAVITGB1 | |
| SCHEMBL6777155 | 0.79 | ITGB3 (0.48) | MEN1KMT2AITGB3ITGAVITGB1 | |
| SCHEMBL6776873 | 0.78 | MEN1 (0.44) | MEN1KMT2AITGB3ITGAVITGB1 | |
| SCHEMBL6774904 | 0.78 | GPR132 (0.47) | ITGB3ITGAVITGB1ITGA2BITGB5 | |
| SCHEMBL6776933 | 0.78 | MEN1 (0.40) | MEN1KMT2AITGB3ITGAVITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |