Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961269 | 1.00 | GRM5 (0.43) | GRM5L3MBTL1IDO1MEN1KMT2A | |
| SCHEMBL13167958 | 0.86 | GRM5 (0.47) | GRM5L3MBTL1MEN1KMT2AKDM4C | |
| SCHEMBL3592583 | 0.82 | GRM5 (0.46) | GRM5KIF11 | |
| SCHEMBL8165987 | 0.77 | GRM5 (0.41) | GRM5IDO1 | |
| SCHEMBL7972568 | 0.77 | GRM5 (0.41) | GRM5IDO1 | |
| SCHEMBL7976303 | 0.75 | ADRA1A (0.38) | GRM5L3MBTL1IDO1MEN1KMT2A | |
| SCHEMBL7976298 | 0.75 | ADRA1A (0.38) | GRM5L3MBTL1IDO1MEN1KMT2A | |
| SCHEMBL7872587 | 0.73 | GRM5 (0.39) | GRM5 | |
| SCHEMBL15181377 | 0.73 | GRM5 (0.36) | GRM5MEN1KMT2AKDM4C | |
| SCHEMBL2836304 | 0.72 | GRM5 (0.43) | GRM5IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019052-A4 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1019052-A1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-2000027817-A1 | OXAZOLIDINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-1998057640-A1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |