Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976303 | 1.00 | ADRA1A (0.38) | ADRA1AADRA1BADRA1DHRH1MEN1 | |
| SCHEMBL6953243 | 0.83 | MGLL (0.38) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7972617 | 0.79 | ADRA1A (0.39) | ADRA1AADRA1BADRA1DHRH1HCRTR2 | |
| SCHEMBL7083166 | 0.78 | ADRA1A (0.40) | ADRA1AADRA1BADRA1DHRH1IDO1 | |
| SCHEMBL7083169 | 0.78 | ADRA1A (0.40) | ADRA1AADRA1BADRA1DHRH1IDO1 | |
| SCHEMBL7075810 | 0.78 | ADRA1A (0.40) | ADRA1AADRA1BADRA1DHRH1IDO1 | |
| SCHEMBL6961269 | 0.75 | GRM5 (0.43) | MEN1KMT2AIDO1P2RX3L3MBTL1 | |
| SCHEMBL7843744 | 0.75 | GRM5 (0.43) | MEN1KMT2AIDO1P2RX3L3MBTL1 | |
| SCHEMBL6961064 | 0.71 | ADRA1A (0.41) | ADRA1AADRA1BADRA1DHRH1USP5 | |
| SCHEMBL6961998 | 0.71 | ADRA1A (0.41) | ADRA1AADRA1BADRA1DHRH1USP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228870-B1 | BENIGN PROSTATIC HYPERPLASIA; REDUCTION OF HYPOTENSION SIDE EFFECT | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |
| US-6143750-A | NITROGEN HETEROCYCLIC COMPOUNDS AS ENZYME INHIBITORS, FOR PROSTATE PROBLEMS AND MUSCLE RELAXANTS | MERCK & CO., INC. (US) | 2000-11-07 | — | — | US | disclosed |