Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846456 | 0.90 | PTGDR2 (0.59) | PTGDR2PTGS2PTGS1 | |
| SCHEMBL7839771 | 0.84 | CA1 (0.54) | PTGDR2MEN1KMT2APTGS2PTGS1 | |
| SCHEMBL7846460 | 0.80 | PTGDR2 (0.57) | PTGDR2MEN1KMT2APTGS2MAPT | |
| SCHEMBL7844920 | 0.79 | PTGS2 (0.61) | PTGDR2MEN1KMT2APTGS2PTGS1 | |
| SCHEMBL7843369 | 0.78 | CCNA2 (0.52) | PTGDR2MEN1KMT2APTGS2PTGS1 | |
| SCHEMBL7843975 | 0.78 | PTGS2 (0.56) | MEN1KMT2APTGS2MAPTSMN1; SMN2 | |
| SCHEMBL7841561 | 0.77 | PTGS2 (0.71) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL7846075 | 0.77 | PTGS2 (0.57) | PTGS2PTGS1MAPT | |
| SCHEMBL208098 | 0.77 | MAPT (0.63) | PTGDR2MEN1KMT2APTGS2MAPT | |
| SCHEMBL7832857 | 0.76 | SMN1; SMN2 (0.58) | MEN1KMT2APTGS2PTGS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |