Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188647 | 0.97 | AKR1B1 (0.39) | AKR1B1LMNATP53ALDH1A1KDM4E | |
| SCHEMBL17084530 | 0.84 | CYP2A6 (0.54) | LMNATP53CA2CYP1A2CYP2A6 | |
| SCHEMBL7432912 | 0.80 | CYP1A2 (0.57) | LMNAALDH1A1KDM4EGAAHPGD | |
| SCHEMBL7840203 | 0.80 | AKR1B1 (0.43) | AKR1B1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL29871774 | 0.74 | LMNA (0.50) | LMNATP53KDM4ECA2CYP1A2 | |
| SCHEMBL4194127 | 0.74 | LMNA (0.50) | LMNATP53KDM4ECA2CYP1A2 | |
| SCHEMBL18716081 | 0.72 | LMNA (0.49) | LMNATP53CA2CYP1A2CYP2A6 | |
| SCHEMBL9644313 | 0.72 | CYP2A6 (0.56) | AKR1B1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL7843943 | 0.71 | CYP1A2 (0.54) | AKR1B1LMNAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL21675665 | 0.70 | PTPN1 (0.49) | LMNATP53KDM4ECA2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984963-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-11 | — | — | EP | disclosed |