Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843889 | 1.00 | PLAU (0.37) | PLAUCCR1CCR5CCR8ALDH1A1 | |
| SCHEMBL7847263 | 0.82 | KDM4E (0.40) | PLAUCCR1CCR5CCR8ALDH1A1 | |
| SCHEMBL7847265 | 0.82 | KDM4E (0.40) | PLAUCCR1CCR5CCR8ALDH1A1 | |
| SCHEMBL7842808 | 0.79 | AAK1 (0.37) | ABL1BCRMAPTHDAC1 | |
| SCHEMBL7843894 | 0.72 | CTSL (0.34) | CCR1CCR5CCR8ALDH1A1USP2 | |
| SCHEMBL7846734 | 0.69 | CNR1 (0.39) | PLAUCCR1CCR5CCR8ABL1 | |
| SCHEMBL7230744 | 0.69 | AAK1 (0.40) | CCR1CCR5CCR8ABL1BCR | |
| SCHEMBL7846731 | 0.69 | CNR1 (0.39) | PLAUCCR1CCR5CCR8ABL1 | |
| SCHEMBL7239061 | 0.69 | AAK1 (0.41) | PLAUCCR1CCR5CCR8 | |
| SCHEMBL7232327 | 0.69 | CCR1 (0.38) | PLAUCCR1CCR5CCR8ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |