Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853175 | 0.89 | KDM4E (0.40) | AAK1TP53MAPTTHRBTDP1 | |
| SCHEMBL7841629 | 0.85 | ACACB (0.35) | AAK1CNR1ACACBACACA | |
| SCHEMBL7846551 | 0.84 | CNR1 (0.52) | TP53MAPTTDP1LMNANPSR1 | |
| SCHEMBL7238064 | 0.81 | AAK1 (0.41) | AAK1CNR1ACACBACACA | |
| SCHEMBL7845048 | 0.79 | KDR (0.41) | — | |
| SCHEMBL7846741 | 0.79 | AAK1 (0.38) | AAK1TP53THRBCYP1A2CYP3A4 | |
| SCHEMBL23246323 | 0.78 | L3MBTL1 (0.44) | MAPTLMNANPSR1POLBALDH1A1 | |
| SCHEMBL29707255 | 0.78 | L3MBTL1 (0.44) | MAPTLMNANPSR1POLBALDH1A1 | |
| SCHEMBL28739389 | 0.78 | ALDH1A1 (0.44) | MAPTTDP1LMNAALDH1A1 | |
| SCHEMBL23246313 | 0.78 | L3MBTL1 (0.44) | MAPTLMNANPSR1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |