Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814705 | 0.89 | SMN1; SMN2 (0.48) | DRD4DRD2PPARGPPARAALDH1A1 | |
| SCHEMBL6814945 | 0.88 | HTR7 (0.53) | DRD4DRD2SLC6A4HTR7PPARG | |
| SCHEMBL18601776 | 0.88 | HTR7 (0.53) | DRD4DRD2SLC6A4HTR7PPARG | |
| SCHEMBL8067420 | 0.83 | DRD4 (0.43) | DRD4DRD2PPARGPPARAALDH1A1 | |
| SCHEMBL5463394 | 0.82 | PTGS2 (0.49) | DRD4DRD2PPARGPPARAPTGS2 | |
| SCHEMBL6610239 | 0.82 | PTGS2 (0.49) | DRD4DRD2PPARGPPARAPTGS2 | |
| SCHEMBL5453693 | 0.82 | PPARA (0.49) | DRD4DRD2SLC6A4HTR7PPARG | |
| SCHEMBL5453689 | 0.82 | PPARA (0.49) | DRD4DRD2SLC6A4HTR7PPARG | |
| SCHEMBL10040989 | 0.79 | SMN1; SMN2 (0.46) | DRD4DRD2ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7785539 | 0.77 | CYP1A2 (0.49) | DRD4DRD2SLC6A4HTR7PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140913-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1137647-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034268-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |
| WO-2000034269-A1 | THIOUREA INHIBITORS OF HERPES VIRUSES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |