Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844809 | 0.93 | MAOB (0.48) | PTGS2TP53MAOBRORCCNR1 | |
| SCHEMBL7843859 | 0.93 | TP53 (0.43) | PTGS2TP53MDM2MAOBCNR1 | |
| SCHEMBL7841881 | 0.92 | PTGS2 (0.46) | PTGS2TP53MDM2MAOBCNR1 | |
| SCHEMBL7832865 | 0.92 | PTGS2 (0.44) | PTGS2MAOBRORCALOX5MAPT | |
| SCHEMBL7842469 | 0.91 | MAOB (0.47) | PTGS2MAOBALOX5MAPT | |
| SCHEMBL7841078 | 0.90 | PTGS2 (0.48) | PTGS2TP53MDM2MAOBALOX5 | |
| SCHEMBL7842485 | 0.88 | MAOB (0.50) | PTGS2MAOBRORCALOX5 | |
| SCHEMBL7844759 | 0.88 | THRB (0.43) | PTGS2MAOBRORCALOX5 | |
| SCHEMBL7847000 | 0.87 | PTGS2 (0.46) | PTGS2TP53MAOBMAPT | |
| SCHEMBL7843760 | 0.86 | PTGS2 (0.45) | PTGS2MAOBALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |