Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843267 | 0.93 | MAOB (0.48) | MAOBCNR1MAPTCNR2PTGS2 | |
| SCHEMBL7844201 | 0.93 | PTGS2 (0.43) | MAOBCNR1MAPTPTGS2RORC | |
| SCHEMBL7842485 | 0.92 | MAOB (0.50) | MAOBPTGS2RORC | |
| SCHEMBL7841881 | 0.90 | PTGS2 (0.46) | MAOBCNR1MAPTPTGS2TP53 | |
| SCHEMBL7841078 | 0.90 | PTGS2 (0.48) | MAOBMAPTPTGS2TP53 | |
| SCHEMBL7844759 | 0.90 | THRB (0.43) | MAOBPTGS2RORC | |
| SCHEMBL7842469 | 0.89 | MAOB (0.47) | MAOBMAPTPTGS2 | |
| SCHEMBL7832865 | 0.88 | PTGS2 (0.44) | MAOBMAPTPTGS2RORC | |
| SCHEMBL7843264 | 0.87 | PTGS2 (0.56) | MAOBPTGS2 | |
| SCHEMBL7844808 | 0.87 | PTGS2 (0.56) | MAOBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |