Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842580 | 0.93 | PTGS2 (0.43) | L3MBTL1PTGS2ADORA3ADORA2AADORA2B | |
| SCHEMBL7832325 | 0.93 | PTGS2 (0.45) | PTGS2LMNASMN1; SMN2PTGS1F10 | |
| SCHEMBL7842512 | 0.92 | ESRRG (0.48) | PTGS2LMNASMN1; SMN2PTGS1KMT2A | |
| SCHEMBL7842757 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1F10KMT2AMEN1 | |
| SCHEMBL7842353 | 0.90 | NPC1 (0.48) | PTGS2SMN1; SMN2PTGS1KMT2AMEN1 | |
| SCHEMBL7845585 | 0.89 | GRM5 (0.43) | PTGS2LMNASMN1; SMN2PTGS1KMT2A | |
| SCHEMBL7841016 | 0.89 | PTGS2 (0.46) | PTGS2SMN1; SMN2PTGS1KMT2AMEN1 | |
| SCHEMBL7845840 | 0.88 | NPSR1 (0.45) | PTGS2PTGS1MAPTNPSR1RAB9A | |
| SCHEMBL7842577 | 0.86 | PTGS2 (0.56) | PTGS2ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7844200 | 0.86 | PTGS2 (0.56) | PTGS2ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |