Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841016 | 0.93 | PTGS2 (0.46) | PTGS2PTGS1ALOX5MAPTNPC1 | |
| SCHEMBL7842512 | 0.92 | ESRRG (0.48) | PTGS2PTGS1ALOX5MAPTNPC1 | |
| SCHEMBL7844026 | 0.92 | NPSR1 (0.45) | NPSR1RXFP1PTGS2ALOX5MAPT | |
| SCHEMBL7842353 | 0.92 | NPC1 (0.48) | PTGS2PTGS1ALOX5MAPTNPC1 | |
| SCHEMBL7832325 | 0.91 | PTGS2 (0.45) | NPSR1RXFP1PTGS2PTGS1ALOX5 | |
| SCHEMBL7841896 | 0.89 | MAPT (0.46) | PTGS2ALOX5MAPTNPC1RAB9A | |
| SCHEMBL7842757 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1MAPTNPC1RAB9A | |
| SCHEMBL7844202 | 0.88 | L3MBTL1 (0.44) | NPSR1PTGS2PTGS1MAPTNPC1 | |
| SCHEMBL7845585 | 0.88 | GRM5 (0.43) | PTGS2PTGS1ALOX5MAPTNPC1 | |
| SCHEMBL7843511 | 0.86 | PTGS2 (0.45) | PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |