SCHEMBL7844324

SCHEMBL7844324

COC(=O)c1nc(N(C)C)ccc1OCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.45
LMNA P02545 1/20 0.45
SMPD1 P17405 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
BRD4 O60885 1/20 0.43
RNASEH1 O60930 1/20 0.43
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
HSD17B10 Q99714 1/20 0.42
APP P05067 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
PRMT5 O14744 1/20 0.41
NOX1 Q9Y5S8 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
EGFR P00533 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9559486 0.89 MEN1 (0.43) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL4699590 0.83 HPGD (0.51) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL4703419 0.82 SMPD1 (0.48) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL30497608 0.82 SMPD1 (0.48) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL7845570 0.82 GAA (0.48) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL595556 0.82 SMPD1 (0.48) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL7846608 0.81 L3MBTL1 (0.46) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL7846688 0.80 HTR1A (0.49) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL8324647 0.79 BRD4 (0.54) HPGDLMNASMPD1HDAC1HDAC8
SCHEMBL5583772 0.79 PTPN1 (0.47) HPGDLMNASMPD1HDAC1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0507962-B1 PICOLINIC ACID DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO (JP) 2001-06-13 EP disclosed
EP-0567133-B1 Picolinic acid derivatives and herbicidal compositions KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-11-03 EP disclosed
US-5403816-A Picolinic acid derivative and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-04 US disclosed
US-5391537-A Picolinic acid derivative, and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-02-21 US disclosed
EP-0567133-A1 Picolinic acid derivative and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1993-10-27 EP disclosed
EP-0507962-A1 PICOLINIC ACID DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1992-10-14 EP disclosed