Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840954 | 0.81 | POLB (0.53) | POLBALDH1A1KDM4EMCHR1MEN1 | |
| SCHEMBL7838418 | 0.80 | MEN1 (0.48) | POLBALDH1A1GAAMEN1KMT2A | |
| SCHEMBL17009523 | 0.78 | KMT2A (0.46) | POLBALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5592248 | 0.76 | OPRD1 (0.55) | POLBGAALMNATDP1OPRD1 | |
| SCHEMBL30196140 | 0.76 | NPC1 (0.49) | ALDH1A1MEN1KMT2ALMNAOPRD1 | |
| SCHEMBL30136060 | 0.75 | POLB (0.56) | POLBALDH1A1KDM4ELMNATDP1 | |
| SCHEMBL1447090 | 0.72 | OPRD1 (0.56) | POLBMEN1KMT2ALMNAOPRD1 | |
| SCHEMBL2226706 | 0.71 | GAA (0.55) | POLBALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL7842738 | 0.71 | POLB (0.45) | POLBALDH1A1KDM4EMCHR1OPRD1 | |
| SCHEMBL31722560 | 0.71 | POLB (0.55) | POLBALDH1A1KDM4EGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |