Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840407 | 0.85 | OPRD1 (0.48) | MEN1KMT2AALDH1A1OPRK1OPRD1 | |
| SCHEMBL7831085 | 0.82 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1GAAOPRK1 | |
| SCHEMBL17009523 | 0.81 | KMT2A (0.46) | MEN1KMT2AALDH1A1OPRK1OPRD1 | |
| SCHEMBL7844521 | 0.80 | POLB (0.58) | MEN1KMT2AALDH1A1GAAOPRK1 | |
| SCHEMBL30196140 | 0.76 | NPC1 (0.49) | MEN1KMT2AALDH1A1OPRK1OPRD1 | |
| SCHEMBL7839195 | 0.74 | HRH2 (0.39) | MEN1KMT2AALDH1A1OPRK1OPRD1 | |
| SCHEMBL7839962 | 0.73 | LMNA (0.44) | ALDH1A1OPRK1OPRD1LMNAHRH2 | |
| SCHEMBL30136060 | 0.73 | POLB (0.56) | ALDH1A1OPRK1OPRD1LMNAHRH2 | |
| SCHEMBL7832576 | 0.72 | GPR119 (0.48) | ALDH1A1GAAOPRK1OPRD1LMNA | |
| SCHEMBL5592248 | 0.72 | OPRD1 (0.55) | GAAOPRK1OPRD1LMNAHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |