Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TET3 | O43151 | 2/20 | 0.51 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.51 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.51 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.51 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.51 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.51 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27472889 | 0.90 | OPRD1 (0.57) | OPRD1OPRK1OPRM1SLC22A1SLC6A4 | |
| SCHEMBL9037444 | 0.89 | OPRD1 (0.51) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL6248104 | 0.89 | KMT2A (0.54) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL8438413 | 0.88 | SMN1; SMN2 (0.55) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL8915729 | 0.87 | OPRM1 (0.53) | OPRD1OPRK1KMT2AMEN1TET3 | |
| SCHEMBL5592248 | 0.84 | OPRD1 (0.55) | OPRD1OPRK1OPRM1LMNAPOLB | |
| SCHEMBL16244835 | 0.82 | OPRD1 (0.57) | OPRD1OPRK1OPRM1LMNAPOLB | |
| SCHEMBL8824371 | 0.82 | OPRD1 (0.54) | OPRD1OPRK1OPRM1LMNAPOLB | |
| SCHEMBL8824367 | 0.81 | OPRD1 (0.53) | OPRD1OPRK1OPRM1ADRA1ALMNA | |
| SCHEMBL8122193 | 0.81 | OPRD1 (0.53) | OPRD1OPRK1OPRM1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297153-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009131940-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |
| EP-1077942-A1 | CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059972-A1 | CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-11-25 | — | — | WO | disclosed |
| EP-0946545-A1 | NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| EP-0946548-A1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027086-A1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1998-06-25 | — | — | WO | disclosed |
| WO-1998027085-A1 | NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1998-06-25 | — | — | WO | disclosed |