Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | FAP | Q12884 | 2/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 4/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852243 | 0.87 | FAP (0.49) | ACKR3FAPCAPN1ACEACE2 | |
| SCHEMBL7855090 | 0.85 | CTSL (0.46) | ACEACE2 | |
| SCHEMBL7851487 | 0.85 | SIGMAR1 (0.48) | SIGMAR1ACKR3CAPN1ACE2EPHX2 | |
| SCHEMBL7845289 | 0.83 | ACE (0.59) | ACEACE2TSHR | |
| SCHEMBL7855038 | 0.83 | KDM4E (0.58) | ACEACE2 | |
| SCHEMBL7853840 | 0.83 | EPHX2 (0.48) | ACEACE2EPHX2LTA4H | |
| SCHEMBL7843734 | 0.82 | NPC1 (0.51) | ACEACE2EPHX2TSHRLTA4H | |
| SCHEMBL7843759 | 0.82 | NPC1 (0.45) | FAPACEACE2EPHX2TSHR | |
| SCHEMBL7844672 | 0.81 | HTRA1 (0.52) | ACEACE2TSHR | |
| SCHEMBL7856866 | 0.81 | ACE (0.55) | ACEACE2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |