Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 6/20 | 0.64 |
| ▸ | CTSL | P07711 | 6/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.48 |
| ▸ | C5AR1 | P21730 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10934405 | 0.78 | SIRT2 (0.76) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL7835152 | 0.77 | CTSV (0.81) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL7844745 | 0.77 | CTSV (0.59) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL30968206 | 0.76 | MEN1 (0.65) | CTSVCTSLMEN1KMT2AKDM4E | |
| SCHEMBL25311441 | 0.74 | CTSV (0.65) | CTSVCTSLSIRT2KDM4ECHRM4 | |
| SCHEMBL9653543 | 0.71 | C5AR1 (0.59) | CTSVCTSLC5AR1MEN1KMT2A | |
| SCHEMBL10937794 | 0.70 | SIRT2 (0.61) | CTSVCTSLSIRT2MEN1KMT2A | |
| SCHEMBL4481551 | 0.70 | MEN1 (0.67) | MEN1KMT2AKDM4EMAPTCYP2C9 | |
| SCHEMBL11548021 | 0.70 | NPC1 (0.68) | C5AR1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL10934422 | 0.70 | SIRT2 (0.60) | CTSVCTSLSIRT2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |