Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | UBE2N | P61088 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848279 | 0.88 | CYP2D6 (0.47) | CCR5CYP2D6 | |
| SCHEMBL7843983 | 0.81 | MEN1 (0.41) | CCR5CYP2D6MAPK1UBE2NNPSR1 | |
| SCHEMBL7835611 | 0.81 | CCR5 (0.46) | CCR5CYP2D6MAPK1UBE2NNPSR1 | |
| SCHEMBL7834484 | 0.80 | — | — | |
| SCHEMBL7844674 | 0.79 | CCR5 (0.49) | CCR5CYP2D6MAPK1UBE2NNPSR1 | |
| SCHEMBL7834134 | 0.74 | CCR5 (0.45) | CCR5CYP2D6MAPK1UBE2NNPSR1 | |
| SCHEMBL7835350 | 0.73 | CYP2D6 (0.44) | CCR5CYP2D6 | |
| SCHEMBL7844278 | 0.72 | CCR5 (0.48) | CCR5CYP2D6MAPK1UBE2NNPSR1 | |
| SCHEMBL7834120 | 0.72 | CYP2D6 (0.46) | CCR5CYP2D6MAPK1UBE2NNPSR1 | |
| SCHEMBL7845819 | 0.71 | CCR5 (0.44) | CCR5CYP2D6MAPK1UBE2NNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-B1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | claimed |