Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 12/20 | 0.73 |
| ▸ | PRKCA | P17252 | 12/20 | 0.73 |
| ▸ | PRKCE | Q02156 | 9/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | JAK1 | P23458 | 1/20 | 0.64 |
| ▸ | TYK2 | P29597 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842285 | 0.84 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7830883 | 0.84 | PRKCB (0.80) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7842615 | 0.83 | PRKCB (0.94) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7843214 | 0.83 | PRKCA (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7840914 | 0.82 | PRKCB (0.87) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7830800 | 0.82 | PRKCA (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7839539 | 0.81 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7843569 | 0.80 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7843888 | 0.80 | PRKCA (0.81) | PRKCBPRKCAPRKCEJAK2JAK1 | |
| SCHEMBL7832843 | 0.80 | PRKCB (1.00) | PRKCBPRKCAPRKCEJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | claimed |
| WO-2013029043-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2013-02-28 | — | — | WO | disclosed |
| EP-1120414-A1 | DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | JAPAN TOBACCO INC. (JP) | 2001-08-01 | — | — | EP | disclosed |