Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846570 | 0.84 | ALDH1A1 (0.68) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL312516 | 0.84 | PDE10A (0.64) | KDM4EALDH1A1MAPTTP53PDE10A | |
| SCHEMBL5452156 | 0.84 | ALDH1A1 (0.56) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7846516 | 0.84 | RAD52 (0.51) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1346973 | 0.81 | PDE10A (0.47) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5452103 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7845119 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7849116 | 0.78 | ALDH1A1 (0.51) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1348546 | 0.78 | PDE10A (0.44) | KDM4EALDH1A1TP53PDE10ANPC1 | |
| SCHEMBL1348413 | 0.78 | CCNE1 (0.44) | KDM4EALDH1A1TP53PDE10ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |