Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.61 |
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849116 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7845288 | 0.84 | KDM4E (0.48) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL14545210 | 0.84 | KDM4E (0.51) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL5452156 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL5452103 | 0.84 | KDM4E (0.56) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7847041 | 0.84 | S100A4 (0.56) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7847688 | 0.81 | KDM4E (0.44) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7845119 | 0.79 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL14827419 | 0.78 | FUBP1 (0.56) | ALDH1A1KDM4EMAPTTP53SMN1; SMN2 | |
| SCHEMBL7843308 | 0.78 | CCNT1 (0.45) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |