Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845288 | 0.84 | KDM4E (0.48) | CDK2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL5452156 | 0.83 | ALDH1A1 (0.56) | RAD52CDK2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7847041 | 0.83 | S100A4 (0.56) | RAD52KCNN3CDK2KDM4EMEN1 | |
| SCHEMBL5456702 | 0.80 | CCNT1 (0.58) | EGLN2KDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7846659 | 0.75 | HSP90AA1 (0.49) | EGLN2KCNN3CDK2SMN1; SMN2NPC1 | |
| SCHEMBL7846570 | 0.75 | ALDH1A1 (0.68) | CDK2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7849116 | 0.75 | ALDH1A1 (0.51) | RAD52CDK2KDM4EMEN1ALDH1A1 | |
| SCHEMBL19784 | 0.74 | CDK2 (0.51) | RAD52CDK2KDM4EMEN1ALDH1A1 | |
| SCHEMBL5460449 | 0.74 | CHEK1 (0.42) | CDK2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL30974 | 0.73 | PDE10A (0.67) | KCNN3CDK2PDE10ACHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |