Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HK1 | P19367 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GALK1 | P51570 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720559 | 0.81 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDMEN1MAPT | |
| Hydrochloric Acid SCHEMBL3154489 | 0.79 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL7837771 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1HPGD | |
| SCHEMBL1868060 | 0.68 | ALDH1A1 (0.36) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL3081411 | 0.67 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL8275 | 0.67 | RYR2 (0.31) | KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6424274 | 0.65 | RYR2 (0.31) | — | |
| SCHEMBL7730853 | 0.65 | TRPA1 (0.59) | KDM4EHPGDMEN1NPC1HSP90AA1 | |
| SCHEMBL7994953 | 0.65 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDMEN1MAPT | |
| Thioxanthene SCHEMBL27774542 | 0.65 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |