Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 17/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.71 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636661 | 0.90 | MPO (0.72) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL4637101 | 0.89 | MPO (0.73) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL387663 | 0.83 | MPO (1.00) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL2406225 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL2122451 | 0.83 | MPO (0.75) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL8261020 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL7871799 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL733767 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL517983 | 0.83 | MPO (0.73) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL31620029 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| CN-1304403-A | N-aryloxyethyl-indoly-alkylamines for treatment of depression (5-HT1A receptor active agents) | AMERICAN HOME PROD (US) | 2001-07-18 | — | — | CN | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |