Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 17/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.71 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30969154 | 0.83 | MPO (0.75) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL31620029 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL7845587 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL2406225 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL733767 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL387663 | 0.83 | MPO (1.00) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL8261020 | 0.83 | MPO (0.71) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL517983 | 0.83 | MPO (0.73) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL2122451 | 0.83 | MPO (0.75) | MPOHTR2ATRPM8GPR84HTR1A | |
| SCHEMBL29571866 | 0.83 | MPO (0.73) | MPOHTR2ATRPM8GPR84HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808303-B1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0808303-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024582-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1996-08-15 | — | — | WO | disclosed |