SCHEMBL7845753

SCHEMBL7845753

Nc1ncccc1OCCCCN1C(=O)COC1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HTT P42858 1/20 0.40
LTA4H P09960 1/20 0.40
MAPK14 Q16539 1/20 0.40
MAPT P10636 1/20 0.35
DRD2 P14416 3/20 0.34
HTR2A P28223 1/20 0.34
MCHR1 Q99705 1/20 0.34
KCNH2 Q12809 2/20 0.34
CHRM1 P11229 1/20 0.34
REN P00797 1/20 0.34
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
HTR1A P08908 1/20 0.33
CYP2C9 P11712 1/20 0.33
HTR1D P28221 1/20 0.33
HTR1B P28222 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7846002 0.79 ALDH1A1 (0.44) NPC1RAB9ASMN1; SMN2HTTLTA4H
SCHEMBL7845952 0.79 SSTR4 (0.36) SMN1; SMN2DRD2HTR2AMCHR1KCNH2
SCHEMBL2458779 0.78 TDP1 (0.55) HTR2AKDM4EHTR1B
SCHEMBL7845965 0.75 ALDH1A1 (0.45) NPC1RAB9ASMN1; SMN2HTTLTA4H
SCHEMBL23850962 0.70 LTA4H (0.54) NPC1RAB9ASMN1; SMN2HTTLTA4H
SCHEMBL18970261 0.70 LTA4H (0.54) NPC1RAB9ASMN1; SMN2HTTLTA4H
SCHEMBL7844990 0.70 LTA4H (0.54) NPC1RAB9ASMN1; SMN2HTTLTA4H
SCHEMBL10644141 0.69 CYP1A2 (0.53) NPC1RAB9ASMN1; SMN2HTTLTA4H
SCHEMBL7245903 0.69 KDM4E (0.60) SMN1; SMN2HTR2AKCNH2CHRM1KDM4E
SCHEMBL11084194 0.68 LTA4H (0.56) NPC1RAB9ASMN1; SMN2HTTLTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767790-B1 CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-12-12 EP disclosed
US-5840732-A ANTIDIABETIC AGENTS, AUTOIMMUNE DISEASES OR IMMUNOSUPPRESSANTS TAKEDA CHEMICAL INDUSTRIES LTD. (JP) 1998-11-24 US disclosed
EP-0767790-A1 CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-04-16 EP disclosed
WO-1995035296-A1 CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-12-28 WO disclosed