Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846002 | 0.96 | ALDH1A1 (0.44) | ALDH1A1NR1H2NR1H3SMN1; SMN2HSD17B10 | |
| SCHEMBL7844901 | 0.77 | ALDH1A1 (0.43) | ALDH1A1NR1H2NR1H3SMN1; SMN2HSD17B10 | |
| SCHEMBL7845753 | 0.75 | NPC1 (0.40) | ALDH1A1SMN1; SMN2LTA4HMAPK14NPC1 | |
| SCHEMBL7842563 | 0.74 | ALDH1A1 (0.42) | ALDH1A1NR1H2NR1H3SMN1; SMN2HSD17B10 | |
| SCHEMBL7878513 | 0.69 | MAPT (0.53) | ALDH1A1NR1H2NR1H3SMN1; SMN2HSD17B10 | |
| SCHEMBL7245903 | 0.69 | KDM4E (0.60) | ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7845274 | 0.69 | ALDH1A1 (0.44) | ALDH1A1NR1H2NR1H3SMN1; SMN2HSD17B10 | |
| SCHEMBL4776890 | 0.68 | HTR1A (0.56) | ALDH1A1GAA | |
| SCHEMBL11084194 | 0.68 | LTA4H (0.56) | SMN1; SMN2LTA4HMAPK14RECQLMEN1 | |
| SCHEMBL7843486 | 0.68 | LTA4H (0.56) | SMN1; SMN2LTA4HMAPK14RECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767790-B1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5840732-A | ANTIDIABETIC AGENTS, AUTOIMMUNE DISEASES OR IMMUNOSUPPRESSANTS | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0767790-A1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-04-16 | — | — | EP | disclosed |
| WO-1995035296-A1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-12-28 | — | — | WO | disclosed |