Acetamide

Acetamide

SCHEMBL7845790

CC(N)=O.O=S(=O)(O)c1ccccc1

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of Acetamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.73
SMN1; SMN2 Q16637 2/20 0.73
CYP2D6 P10635 2/20 0.50
POLB P06746 1/20 0.50
ALDH1A1 P00352 3/20 0.48
NT5E P21589 1/20 0.48
CYP2C19 P33261 1/20 0.47
BCAT1 P54687 1/20 0.47
HSD17B10 Q99714 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA3 P07451 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA5A P35218 1/20 0.46
CA7 P43166 1/20 0.46
PLA2G7 Q13093 1/20 0.46
CA9 Q16790 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbamic Acid SCHEMBL28801958 0.91 TSHR (0.80) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
Acetic Acid SCHEMBL365705 0.91 TSHR (0.80) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
Acetone SCHEMBL27970561 0.91 TSHR (0.80) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
Urea SCHEMBL7500665 0.91 TSHR (0.80) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
Urea SCHEMBL27768310 0.88 TSHR (0.76) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL27485433 0.88 TSHR (0.76) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
Acetic Acid SCHEMBL27820715 0.88 TSHR (0.76) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
Methylamine SCHEMBL5875184 0.88 TSHR (0.84) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL27259350 0.88 TSHR (0.61) TSHRSMN1; SMN2CYP2D6POLBALDH1A1
SCHEMBL3965224 0.87 TSHR (0.67) TSHRSMN1; SMN2CYP2D6POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117285514-A Solid forms of HIV capsid inhibitor 吉利德科学公司 2023-12-26 CN claimed
US-5384252-A Cyclization of an unsaturated molecule with sulfonate leaving group THE SCRIPPS RESEARCH INSTITUTE (US) 1995-01-24 US claimed
EP-4608832-A1 2-(4-(2-(7, 8-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A] PYRIDIN-6-YL)-3-ISOPROPYL-1H-INDOL-5-YL)PIPERIDIN-1-YL)ACETAMIDE SALT AND CRYSTALLINE FORMS THEREOF Bristol-Myers Squibb Company (US) 2025-09-03 EP disclosed
WO-2025106462-A1 2-(4-(2-(7, 8-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A] PYRIDIN-6-YL)-3-ISOPROPYL-1H-INDOL-5-YL)PIPERIDIN-1-YL)ACETAMIDE SALT AND CRYSTALLINE FORMS THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-22 WO disclosed
CN-117285514-A Solid forms of HIV capsid inhibitor 吉利德科学公司 2023-12-26 CN disclosed
WO-2023086320-A1 FORMS AND COMPOSITIONS OF INHIBITORS OF JAK2 AJAX THERAPEUTICS, INC. (US) 2023-05-19 WO disclosed
CN-103501777-A Pharmaceutically acceptable cocrystal of N- [2- (7-methoxy-1-naphthyl) ethyl ] acetamide and preparation method thereof ZENTIVA KS 2014-01-08 CN disclosed
CN-101437811-A Quinoline derivatives ASTRAZENECA AB (SE) 2009-05-20 CN disclosed
US-6183932-B1 STABLY FORMS QUALITY IMAGE, SIMPLE AND QUICK; POLLUTION CONTROL FUJI PHOTO FILM CO., LTD. (JP) 2001-02-06 US disclosed
US-5384252-A Cyclization of an unsaturated molecule with sulfonate leaving group THE SCRIPPS RESEARCH INSTITUTE (US) 1995-01-24 US disclosed
US-4487725-A Process for the preparation of N-acetylaminoarylsulfonic acids in sulfuric acid as solvent HOECHST AKTIENGESELLSCHAFT (DE) 1984-12-11 US disclosed