Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PCK1 | P35558 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849561 | 0.86 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BALDH1A1HTR6 | |
| SCHEMBL7847548 | 0.76 | KMT2A (0.44) | ADRA1DADRA1AADRA1BALDH1A1SMN1; SMN2 | |
| SCHEMBL7852948 | 0.75 | ADRA1D (1.00) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7849707 | 0.72 | ADRA1D (0.33) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7845310 | 0.67 | ADRA1D (0.55) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7841676 | 0.66 | ADRA1D (0.46) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7845847 | 0.66 | ADRA1D (0.55) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8564106 | 0.62 | ADRA1D (0.37) | ADRA1D | |
| SCHEMBL7849562 | 0.59 | ADRA1D (0.80) | ADRA1DADRA1AADRA1B | |
| SCHEMBL29880132 | 0.59 | CRBN (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831824-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | claimed |
| EP-0831824-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | claimed |
| WO-1996039140-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | claimed |