Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 11/20 | 0.39 |
| ▸ | PGR | P06401 | 5/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841676 | 0.92 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BNR3C1PGR | |
| SCHEMBL7835028 | 0.84 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BNR3C2MAPK1 | |
| SCHEMBL7843141 | 0.80 | ADRA1D (0.57) | ADRA1DADRA1AADRA1BNR3C2KDM4E | |
| SCHEMBL7848095 | 0.75 | NR3C2 (0.32) | ADRA1DADRA1AADRA1BNR3C2 | |
| SCHEMBL7846949 | 0.75 | ROCK2 (0.38) | CYP3A4HSD17B10KDM4E | |
| SCHEMBL7849561 | 0.70 | ADRA1D (0.44) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7843937 | 0.69 | NR3C1 (0.36) | ADRA1DADRA1AADRA1BNR3C1PGR | |
| SCHEMBL7845844 | 0.67 | ADRA1D (0.60) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8564106 | 0.67 | ADRA1D (0.37) | ADRA1DNR3C2 | |
| SCHEMBL7849142 | 0.66 | ADRA1D (0.56) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831824-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | claimed |
| EP-0831824-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | claimed |
| WO-1996039140-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | claimed |
| EP-0831824-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0831824-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039140-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |