Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324900 | 1.00 | CYP19A1 (0.44) | CYP19A1ALOX5KDM4ENPC1RAB9A | |
| SCHEMBL28017683 | 0.90 | ALOX5 (0.43) | CYP19A1ALOX5KDM4ENPC1RAB9A | |
| SCHEMBL31324889 | 0.81 | NPC1 (0.47) | CYP19A1ALOX5KDM4ENPC1RAB9A | |
| SCHEMBL4824051 | 0.81 | IKBKB (0.46) | KDM4ENPC1RAB9AALDH1A1TP53 | |
| SCHEMBL29987215 | 0.79 | IKBKB (0.45) | KDM4ENPC1RAB9AALDH1A1TP53 | |
| SCHEMBL3753723 | 0.77 | RAB9A (0.60) | CYP19A1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL27852488 | 0.77 | ALOX5 (0.36) | CYP19A1ALOX5KDM4ENPC1RAB9A | |
| SCHEMBL29022729 | 0.77 | NPC1 (0.46) | ALOX5KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL25165715 | 0.76 | CYP19A1 (0.39) | CYP19A1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL2581028 | 0.76 | CYP19A1 (0.64) | CYP19A1PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1136493-A1 | 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives | SANOFI-SYNTHELABO (FR) | 2001-09-26 | — | — | EP | disclosed |