Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847399 | 0.88 | TLR7 (0.48) | KDM4ENOS2TLR7ALDH1A1HPGD | |
| SCHEMBL8568147 | 0.82 | NOS2 (0.41) | KDM4ENOS2TLR7NPC1RAB9A | |
| SCHEMBL7842532 | 0.80 | NPC1 (0.62) | KDM4ETLR7ALDH1A1HPGDNPC1 | |
| SCHEMBL7845174 | 0.76 | CDK7 (0.54) | NOS2TLR7HRH2HRH3CCNT1 | |
| SCHEMBL14088335 | 0.75 | KDM4E (0.43) | KDM4ETLR7HPGDNPC1RAB9A | |
| SCHEMBL10623184 | 0.75 | KDM4E (0.43) | KDM4ETLR7HPGDNPC1RAB9A | |
| SCHEMBL14099740 | 0.75 | KDM4E (0.43) | KDM4ETLR7HPGDNPC1RAB9A | |
| SCHEMBL14182277 | 0.75 | KDM4E (0.43) | KDM4ENOS2TLR7HPGDNPC1 | |
| SCHEMBL10388599 | 0.75 | KDM4E (0.66) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10623166 | 0.74 | KDM4E (0.42) | KDM4ENOS2TLR7ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |