Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845874 | 0.82 | KDM4E (0.51) | NOS2TP53TLR7MAOBKDM4E | |
| SCHEMBL18780788 | 0.82 | TLR7 (0.42) | NOS2TLR7KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL18780955 | 0.77 | TLR7 (0.41) | NOS2TLR7ESR1ESR2 | |
| SCHEMBL7003416 | 0.76 | PDE10A (0.54) | NOS2TLR7CCNT1CDK7CDK9 | |
| SCHEMBL25465521 | 0.75 | CYP1A2 (0.39) | TP53MAOBDPP4KDM4ENPC1 | |
| SCHEMBL544920 | 0.75 | RAB9A (0.45) | TP53DPP4KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL21177636 | 0.73 | KDM4E (0.49) | KDM4EESR1ESR2SMN1; SMN2HSD17B10 | |
| SCHEMBL1934522 | 0.73 | PDE10A (0.48) | TP53MAOBDPP4KDM4ESMN1; SMN2 | |
| SCHEMBL545503 | 0.73 | MAOB (0.38) | NOS2TP53TLR7MAOBKDM4E | |
| SCHEMBL10626008 | 0.72 | DPP4 (0.42) | TP53TLR7MAOBDPP4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843951-A | Analgesic composition of pyrazolo(1,5-A) pyrimidines | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0795555-A1 | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1997-09-17 | — | — | EP | disclosed |