Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19871768 | 0.93 | ERN1 (0.46) | ERN1CYP2A6HSP90AA1TLR9MEN1 | |
| SCHEMBL9068487 | 0.89 | CYP2A6 (0.56) | ERN1CYP2A6MEN1KMT2AMAPT | |
| SCHEMBL19862347 | 0.88 | SIRT2 (0.45) | ERN1CYP2A6KDM4EALDH1A1NCEH1 | |
| SCHEMBL56836 | 0.84 | CYP2A6 (0.57) | ERN1CYP2A6MEN1KMT2AMAPT | |
| SCHEMBL16178092 | 0.82 | HSP90AA1 (0.48) | ERN1CYP2A6HSP90AA1TLR9MEN1 | |
| SCHEMBL12260028 | 0.81 | CYP2A6 (0.55) | ERN1CYP2A6MEN1KMT2AMAPT | |
| SCHEMBL646886 | 0.81 | CYP2A6 (0.55) | ERN1CYP2A6MEN1KMT2AMAPT | |
| SCHEMBL5342236 | 0.80 | DHODH (0.40) | ERN1CYP2A6HSP90AA1TLR9MEN1 | |
| SCHEMBL19862341 | 0.80 | TYMS (0.42) | ERN1CYP2A6KDM4EALDH1A1SIRT2 | |
| SCHEMBL19864880 | 0.78 | HSP90AA1 (0.45) | ERN1CYP2A6HSP90AA1TLR9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984963-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-11 | — | — | EP | disclosed |
| US-6162808-A | Compounds | ASTRAZENECA U.K. LIMITED (GB) | 2000-12-19 | — | — | US | disclosed |