Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30538321 | 0.92 | MAPT (0.52) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL10978833 | 0.84 | CYP19A1 (0.58) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL7354479 | 0.81 | CYP3A4 (0.41) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL31661367 | 0.79 | CYP3A4 (0.49) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL27085550 | 0.79 | CYP3A4 (0.49) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL4464552 | 0.77 | MAPT (0.50) | CYP3A4MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL11219318 | 0.74 | HSD17B10 (0.63) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL28718999 | 0.73 | MAPT (0.50) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL28354104 | 0.72 | KDM5A (0.47) | CYP3A4MAPTKDM4ELMNACYP19A1 | |
| SCHEMBL1982985 | 0.71 | CYP3A4 (0.47) | CYP3A4MAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1136493-A1 | 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives | SANOFI-SYNTHELABO (FR) | 2001-09-26 | — | — | EP | disclosed |