Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30538321 | 0.85 | MAPT (0.52) | CYP3A4KDM4EMAPTLMNACYP19A1 | |
| SCHEMBL7846153 | 0.81 | CYP3A4 (0.47) | CYP3A4KDM4EMAPTLMNACYP19A1 | |
| SCHEMBL10978833 | 0.78 | CYP19A1 (0.58) | CYP3A4KDM4EMAPTLMNACYP19A1 | |
| SCHEMBL31661367 | 0.73 | CYP3A4 (0.49) | CYP3A4KDM4EMAPTLMNACYP19A1 | |
| SCHEMBL27085550 | 0.73 | CYP3A4 (0.49) | CYP3A4KDM4EMAPTLMNACYP19A1 | |
| SCHEMBL28329118 | 0.73 | RIPK1 (0.54) | — | |
| SCHEMBL17786644 | 0.71 | LMNA (0.54) | CYP3A4KDM4EMAPTLMNAMTOR | |
| SCHEMBL11219318 | 0.71 | HSD17B10 (0.63) | CYP3A4KDM4EMAPTLMNACYP19A1 | |
| SCHEMBL2653873 | 0.71 | KDM4E (0.47) | KDM4EMAPTMTORADKNISCH | |
| SCHEMBL29852620 | 0.71 | MAPT (0.54) | CYP3A4KDM4EMAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575430-B1 | PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| EP-0575429-B1 | TREATMENT OF COGNITIVE DISORDERS | LUNDBECK & CO AS H (DK) | 1995-12-06 | — | — | EP | disclosed |
| US-5462948-A | Treatment of addiction to drugs and substances of abuse | H. LUNDBECK A/S (DK) | 1995-10-31 | — | — | US | disclosed |
| US-5444073-A | Administering 1-aryl-3-(4-piperidyl)-indole derivatives | H. LUNDBECK A/S (DK) | 1995-08-22 | — | — | US | disclosed |
| EP-0575429-A1 | TREATMENT OF COGNITIVE DISORDERS. | LUNDBECK & CO AS H (DK) | 1993-12-29 | — | — | EP | disclosed |
| EP-0575430-A1 | PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | H. LUNDBECK A/S (DK) | 1993-12-29 | — | — | EP | disclosed |
| WO-1992015302-A1 | TREATMENT OF ADDICTION TO DRUGS AND SUBSTANCES OF ABUSE | H. LUNDBECK A/S (DK) | 1992-09-17 | — | — | WO | disclosed |
| WO-1992015303-A1 | TREATMENT OF COGNITIVE DISORDERS | H. LUNDBECK A/S (DK) | 1992-09-17 | — | — | WO | disclosed |