Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785962 | 1.00 | TRPM8 (0.41) | TRPM8NR1I2HPGDTSHRMAPT | |
| SCHEMBL803191 | 0.90 | TRPM8 (0.40) | TRPM8NR1I2HPGDTSHRMAPT | |
| SCHEMBL784980 | 0.85 | SLC6A2 (0.42) | TRPM8NR1I2HPGDALDH1A1SLC6A2 | |
| SCHEMBL803560 | 0.85 | SLC6A2 (0.42) | TRPM8NR1I2HPGDALDH1A1SLC6A2 | |
| SCHEMBL785967 | 0.85 | TRPM8 (0.47) | TRPM8NR1I2HPGDTSHRMAPT | |
| SCHEMBL785968 | 0.85 | TRPM8 (0.47) | TRPM8NR1I2HPGDTSHRMAPT | |
| SCHEMBL883606 | 0.80 | SLC6A2 (0.41) | TRPM8NR1I2HPGDALDH1A1SLC6A2 | |
| SCHEMBL784054 | 0.78 | HPGD (0.41) | TRPM8HPGDTSHR | |
| SCHEMBL803189 | 0.78 | TRPM8 (0.43) | TRPM8HPGDTSHRMAPTALDH1A1 | |
| SCHEMBL784735 | 0.78 | TRPM8 (0.42) | TRPM8NR1I2NPSR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | TRPM8 180/4885NR1I2 1112/4885HPGD 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.