Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733860 | 0.89 | ELANE (0.56) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL7685083 | 0.89 | ELANE (0.56) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7654203 | 0.88 | ELANE (0.55) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL2313692 | 0.85 | ELANE (0.60) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL2316032 | 0.85 | ELANE (0.60) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL27479845 | 0.84 | LMNA (0.51) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL7464142 | 0.82 | LMNA (0.52) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL6733533 | 0.82 | LMNA (0.52) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL10363040 | 0.81 | ELANE (1.00) | ELANETSHROPRM1OPRD1OPRK1 | |
| SCHEMBL5672094 | 0.81 | ELANE (0.53) | ELANECHRNA7HTR3ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100797-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | Pfizer Limited (GB) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000005232-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |