Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733860 | 1.00 | ELANE (0.56) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7654203 | 0.99 | ELANE (0.55) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL2316032 | 0.96 | ELANE (0.60) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL2313692 | 0.96 | ELANE (0.60) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL7846334 | 0.89 | ELANE (0.67) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL27479845 | 0.85 | LMNA (0.51) | ELANECHRNA7HTR3ALMNASMN1; SMN2 | |
| SCHEMBL6737804 | 0.84 | GABRP (0.50) | ELANESMN1; SMN2MAPTHCRTR1HCRTR2 | |
| SCHEMBL6738108 | 0.83 | GABRP (0.51) | ELANEHCRTR1HCRTR2GABRPGABRD | |
| SCHEMBL6737810 | 0.83 | PTGES (0.56) | HCRTR1HCRTR2GABRPGABRDGABRA1 | |
| SCHEMBL6734526 | 0.83 | ELANE (0.44) | ELANELMNASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372736-B1 | ENZYME INHIBITORS | PFIZER INC | 2002-04-16 | — | — | US | disclosed |
| EP-1098894-A1 | FKBP INHIBITORS | Pfizer Limited (GB) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000005231-A1 | FKBP INHIBITORS | PFIZER LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |