Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025088 | 0.94 | HTR2C (0.49) | HTR2CSLC6A3GPR84IDO1FFAR1 | |
| SCHEMBL452347 | 0.80 | IDO1 (0.50) | GPR84IDO1 | |
| SCHEMBL30639030 | 0.80 | IDO1 (0.53) | HTR2CSLC6A3GPR84IDO1FFAR1 | |
| SCHEMBL2092235 | 0.80 | IDO1 (0.53) | HTR2CSLC6A3GPR84IDO1FFAR1 | |
| SCHEMBL9626216 | 0.79 | IDO1 (0.51) | GPR84IDO1CTSVCTSLCTSS | |
| SCHEMBL448580 | 0.79 | IDO1 (0.51) | GPR84IDO1 | |
| SCHEMBL449978 | 0.77 | IDO1 (0.53) | GPR84IDO1 | |
| SCHEMBL19359157 | 0.76 | IDO1 (0.56) | GPR84IDO1FFAR1 | |
| SCHEMBL7846354 | 0.76 | SLC6A3 (0.46) | HTR2CSLC6A3PPARAMAPTRXFP1 | |
| SCHEMBL10364010 | 0.75 | ALDH1A1 (0.47) | HTR2CSLC6A3GPR84IDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558677-B1 | BIOLOGICALLY ACTIVE AMINES | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5648370-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-07-15 | — | — | US | disclosed |
| EP-0558677-A1 | BIOLOGICALLY ACTIVE AMINES | Astra Pharmaceuticals Limited (GB) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992008708-A1 | BIOLOGICALLY ACTIVE AMINES | FISONS PLC (GB) | 1992-05-29 | — | — | WO | disclosed |