Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 5/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 4/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.55 |
| ▸ | CDK1 | P06493 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 3/20 | 0.55 |
| ▸ | CCND1 | P24385 | 3/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
| ▸ | CDK7 | P50613 | 3/20 | 0.55 |
| ▸ | CCNH | P51946 | 3/20 | 0.55 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.55 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847688 | 0.84 | KDM4E (0.44) | CDK9CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL7846659 | 0.82 | HSP90AA1 (0.49) | CDK9CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL12953039 | 0.82 | PDE10A (0.53) | CDK9CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL5451848 | 0.82 | CCNT1 (0.57) | CDK9CCNT1ALDH1A1KDM4EMEN1 | |
| SCHEMBL5452156 | 0.78 | ALDH1A1 (0.56) | CCNA2CDK2CCNA1CCNE1ALDH1A1 | |
| SCHEMBL30443126 | 0.77 | CCR1 (0.47) | CDK9CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL7846570 | 0.76 | ALDH1A1 (0.68) | CCNA2CDK2CCNA1CCNE1ALDH1A1 | |
| SCHEMBL7849116 | 0.76 | ALDH1A1 (0.51) | CDK9CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL7847041 | 0.75 | S100A4 (0.56) | CDK2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL4431791 | 0.74 | ALDH1A1 (0.50) | CCNA2CDK2CCNA1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |