SCHEMBL7846622

SCHEMBL7846622

O=C1Cc2ccccc2N1c1cccc2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.59
POLB P06746 1/20 0.54
HTR1A P08908 7/20 0.51
HTR7 P34969 5/20 0.51
KDM4E B2RXH2 3/20 0.51
MAPT P10636 2/20 0.51
KMT2A Q03164 2/20 0.51
HTT P42858 1/20 0.51
RECQL P46063 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
PKM P14618 3/20 0.49
HSD17B10 Q99714 2/20 0.49
ALDH1A1 P00352 2/20 0.49
ELANE P08246 1/20 0.47
DDAH1 O94760 1/20 0.47
NOTUM Q6P988 1/20 0.44
TDP1 Q9NUW8 2/20 0.43
CASP3 P42574 1/20 0.43
CASP6 P55212 1/20 0.43
SENP8 Q96LD8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10941014 0.85 POLB (0.52) HPGDPOLBHTR1AHTR7KDM4E
SCHEMBL11084621 0.82 MAPT (0.48) HPGDPOLBHTR1AHTR7KDM4E
SCHEMBL890402 0.78 POLB (0.61) HPGDPOLBHTR1AHTR7KDM4E
SCHEMBL5341408 0.77 MAPT (0.62) HPGDPOLBKDM4EMAPTKMT2A
SCHEMBL4899648 0.77 POLB (0.56) HPGDPOLBHTR1AHTR7KDM4E
SCHEMBL718741 0.75 POLB (0.58) HPGDPOLBHTR1AHTR7KDM4E
SCHEMBL11133610 0.75 HPGD (0.62) HPGDPOLBMAPTKMT2APKM
SCHEMBL7008036 0.75 HPGD (0.62) HPGDMAPTKMT2APKMNOTUM
SCHEMBL7845228 0.75 HPGD (0.57) HPGDPOLBKMT2AALDH1A1NOTUM
SCHEMBL143970 0.74 HPGD (1.00) HPGDHTR1AHTR7KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1105376-A1 OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2001-06-13 EP disclosed
WO-2000010975-A1 OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2000-03-02 WO disclosed