Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938828 | 0.94 | KDM4E (0.48) | KDM4EHRH3SMN1; SMN2RAB9ALMNA | |
| SCHEMBL7938381 | 0.93 | KDM4E (0.47) | KDM4EHRH3SMN1; SMN2RAB9ALMNA | |
| SCHEMBL7937660 | 0.90 | KDM4E (0.44) | KDM4EHRH3SMN1; SMN2RAB9ALMNA | |
| SCHEMBL7936265 | 0.89 | KDM4E (0.44) | KDM4EHRH3SMN1; SMN2RAB9ALMNA | |
| SCHEMBL6810321 | 0.82 | SMN1; SMN2 (0.49) | KDM4EHRH3SMN1; SMN2RAB9ALMNA | |
| SCHEMBL7844242 | 0.71 | MEN1 (0.40) | RAB9ALMNAMAPTMAPK1OPRM1 | |
| SCHEMBL6783042 | 0.70 | LMNA (0.40) | KDM4ESMN1; SMN2RAB9ALMNAMAPT | |
| SCHEMBL27469582 | 0.70 | GPR119 (0.47) | HRH3SMN1; SMN2HIF1AEPAS1KMT2A | |
| SCHEMBL17452233 | 0.69 | LIPE (0.60) | HRH3SMN1; SMN2RAB9ALMNAMAPT | |
| SCHEMBL10397057 | 0.69 | SMN1; SMN2 (0.80) | KDM4EHRH3SMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140850-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6248739-B1 | DNA POLYMERASE INHIBITORS EFFECTIVE AGAINST HERPESVIRUSES | PHARMACIA & UPJOHN COMPANY | 2001-06-19 | — | — | US | disclosed |
| WO-2000040561-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |