Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918644 | 0.93 | PTGS2 (0.49) | PTGS2PTGS1PPARDALOX5 | |
| SCHEMBL7841302 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1PPARDALOX5 | |
| SCHEMBL7833513 | 0.87 | PTGS2 (0.53) | PTGS2PTGS1PPARDALOX5KDM4E | |
| SCHEMBL7844271 | 0.87 | PTGS2 (0.53) | PTGS2PTGS1PPARDALOX5 | |
| SCHEMBL6246548 | 0.87 | PTGS2 (0.65) | PTGS2PTGS1PPARDALOX5 | |
| SCHEMBL7842706 | 0.86 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL7846132 | 0.86 | PTGS2 (0.53) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7843072 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1PPARDALOX5 | |
| SCHEMBL7843634 | 0.85 | PTGS2 (0.55) | PTGS2PTGS1PPARDALOX5 | |
| SCHEMBL7842156 | 0.84 | PTGS2 (0.48) | PTGS2PTGS1PPARDALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |