Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838803 | 0.90 | LMNA (0.76) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7855965 | 0.87 | CYP3A4 (0.65) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7846817 | 0.85 | MAPT (0.78) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7853851 | 0.85 | MAPT (0.66) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL8696236 | 0.85 | LMNA (0.66) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7850581 | 0.85 | KMT2A (0.65) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7853896 | 0.84 | TRPV1 (0.65) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL857812 | 0.84 | MTNR1A (0.57) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7849208 | 0.83 | POLB (0.61) | POLBLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL7848175 | 0.82 | POLB (0.67) | POLBLMNASMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140914-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037462-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |