Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609571 | 0.92 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDNR4A1NR4A2 | |
| SCHEMBL7849474 | 0.86 | CCR1 (0.46) | KDM4EALDH1A1HPGDCCR1CCR8 | |
| SCHEMBL8173359 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1HPGDNR4A1NR4A2 | |
| SCHEMBL7838794 | 0.77 | NR4A1 (0.49) | KDM4EALDH1A1HPGDNR4A1NR4A2 | |
| SCHEMBL30317579 | 0.77 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDNR4A1NR4A2 | |
| SCHEMBL1324771 | 0.76 | NR4A1 (0.64) | KDM4EALDH1A1HPGDNR4A1NR4A2 | |
| SCHEMBL30720582 | 0.76 | NR4A1 (0.64) | KDM4EALDH1A1HPGDNR4A1NR4A2 | |
| SCHEMBL16277390 | 0.76 | SORT1 (0.55) | KDM4EALDH1A1HPGDCCR1CCR8 | |
| SCHEMBL16502669 | 0.76 | KDM4E (0.48) | KDM4EALDH1A1HPGDCCR1CCR8 | |
| SCHEMBL12270088 | 0.75 | CCR1 (0.58) | KDM4EALDH1A1HPGDCCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1335850-A | Quinoline derivatives | SMITHKLINE BEECHMA PLC (GB) | 2002-02-13 | — | — | CN | disclosed |
| EP-1140946-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-10 | — | — | EP | disclosed |
| EP-1047691-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| CN-1260781-A | Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | CN | disclosed |
| WO-2000035919-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-06-22 | — | — | WO | disclosed |
| WO-2000006575-A2 | AZABICYCLIC COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-02-10 | — | — | WO | disclosed |
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1999031086-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-24 | — | — | WO | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |