Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15650824 | 0.84 | LMNA (0.53) | LMNATSHRGAAALDH1A1MAPT | |
| SCHEMBL7917725 | 0.82 | ALDH1A1 (0.48) | LMNATRPV4ERN1HPGDTSHR | |
| SCHEMBL2564265 | 0.82 | ALDH1A1 (0.47) | LMNATRPV4HPGDTSHRGAA | |
| SCHEMBL1949836 | 0.79 | HTT (0.57) | LMNATRPV4HPGDTSHRGAA | |
| SCHEMBL1489970 | 0.78 | TSHR (0.53) | LMNATSHRGAAALDH1A1MAPT | |
| SCHEMBL8496034 | 0.78 | SMN1; SMN2 (0.53) | TRPV4HPGDALDH1A1MAPTKDM4E | |
| SCHEMBL19692878 | 0.78 | MAPT (0.44) | LMNATRPV4HPGDTSHRALDH1A1 | |
| SCHEMBL10507450 | 0.77 | LMNA (0.60) | LMNAGAAALDH1A1MAPTHTT | |
| SCHEMBL30902394 | 0.77 | HPGD (0.64) | LMNAERN1HPGDTSHRGAA | |
| SCHEMBL1185190 | 0.77 | HPGD (0.64) | LMNAERN1HPGDTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1208337-C | Preparation of Xibo ketone | GUANGZHOU BAIYUNSHAN MEDICINE (CN) | 2005-06-29 | — | — | CN | disclosed |
| CN-1176081-C | Intermediate for preparing sildenafic and preparing method thereof | 广州白云山医药科技发展有限公司 | 2004-11-17 | — | — | CN | disclosed |
| CN-1454892-A | Intermediate for preparing sildenafic and preparing method thereof | BAIYUNSHAN MEDICINE SCI & TECH (CN) | 2003-11-12 | — | — | CN | disclosed |
| CN-1406939-A | Preparation of Xibo ketone | BAIYUNSHAN MEDICINE SCIENCE & (CN) | 2003-04-02 | — | — | CN | disclosed |
| WO-2001022918-A2 | METHOD OF PREPARATION OF SILDENAFIL | INST FARMACEUTYCZNY (PL) | 2001-04-05 | — | — | WO | disclosed |