Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1489970 | 0.91 | TSHR (0.53) | ALDH1A1TSHRHTTLMNAMAPT | |
| SCHEMBL12594025 | 0.86 | ALDH1A1 (0.62) | ALDH1A1TSHRHTTTRPV4LMNA | |
| SCHEMBL1949836 | 0.86 | HTT (0.57) | ALDH1A1TSHRHTTTRPV4LMNA | |
| SCHEMBL30184734 | 0.86 | TRPV4 (0.48) | ALDH1A1TSHRHTTTRPV4LMNA | |
| SCHEMBL19692878 | 0.84 | MAPT (0.44) | ALDH1A1TSHRHTTTRPV4LMNA | |
| SCHEMBL11667918 | 0.84 | GAA (0.43) | ALDH1A1TSHRHTTTRPV4LMNA | |
| SCHEMBL8496034 | 0.84 | SMN1; SMN2 (0.53) | ALDH1A1HTTTRPV4MAPTPOLB | |
| SCHEMBL7848014 | 0.82 | LMNA (0.49) | ALDH1A1TSHRHTTTRPV4LMNA | |
| SCHEMBL9388235 | 0.82 | S1PR3 (0.53) | ALDH1A1TSHRHTTLMNAHPGD | |
| SCHEMBL8193976 | 0.81 | CA2 (0.59) | ALDH1A1TSHRHTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133659-A2 | INHIBITORS OF HIF AND ANGIOGENESIS | EMORY UNIVERSITY (US) | 2011-10-27 | — | — | WO | disclosed |